Wednesday, 14 March 2012

Indopril




Indopril may be available in the countries listed below.


Ingredient matches for Indopril



Perindopril

Perindopril erbumine (a derivative of Perindopril) is reported as an ingredient of Indopril in the following countries:


  • Australia

International Drug Name Search

Velban


Generic Name: vinblastine (Intravenous route)

vin-BLAS-teen

Intravenous route(Solution;Powder for Solution)

Intravenous needle or catheter must be properly positioned before any vinblastine is injected as leakage into the surrounding tissue may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis .



Commonly used brand name(s)

In the U.S.


  • Velban

Available Dosage Forms:


  • Solution

  • Powder for Solution

Therapeutic Class: Antineoplastic Agent


Pharmacologic Class: Mitotic Inhibitor


Uses For Velban


Vinblastine belongs to the group of medicines known as antineoplastic agents. It is used to treat certain kinds of cancer, including lymphoma and cancer of the breast or testicles, as well as some noncancerous conditions.


Vinblastine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by vinblastine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, such as hair loss, may not be serious but may cause concern. Some effects do not occur until months or years after the medicine is used.


Before you begin treatment with vinblastine, you and your doctor should talk about the good this medicine will do as well as the risks of using it.


Vinblastine is to be administered only by or under the immediate supervision of your doctor.


Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, vinblastine is used in certain patients with the following medical conditions:


  • Cancer of the bladder

  • Cancer of the kidneys

  • Cancer of the lungs

  • Cancer of the prostate

  • Germ cell ovarian tumors (a certain type of cancer of the ovaries)

  • Malignant melanoma

Before Using Velban


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults.


Geriatric


Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information about the use of vinblastine in the elderly.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.


  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Adenovirus Vaccine Type 4, Live

  • Adenovirus Vaccine Type 7, Live

  • Aprepitant

  • Bacillus of Calmette and Guerin Vaccine, Live

  • Fosaprepitant

  • Influenza Virus Vaccine, Live

  • Itraconazole

  • Lopinavir

  • Measles Virus Vaccine, Live

  • Mitomycin

  • Mumps Virus Vaccine, Live

  • Posaconazole

  • Ritonavir

  • Rotavirus Vaccine, Live

  • Rubella Virus Vaccine, Live

  • Smallpox Vaccine

  • Typhoid Vaccine

  • Varicella Virus Vaccine

  • Voriconazole

  • Yellow Fever Vaccine

  • Zidovudine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Dalfopristin

  • Quinupristin

  • Tolterodine

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Chickenpox (including recent exposure) or

  • Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body

  • Gout (history of) or

  • Kidney stones (history of)—Vinblastine may increase levels of uric acid in the body, which can cause gout or kidney stones

  • Infection—Vinblastine may decrease your body's ability to fight infection

  • Liver disease—Effects may be increased because of slower removal of vinblastine from the body

Proper Use of Velban


Vinblastine is sometimes given together with certain other medicines. If you are using a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your health care professional to help you plan a way to take them at the right times.


While you are using this medicine, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well.


Vinblastine sometimes causes nausea and vomiting. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


Precautions While Using Velban


It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.


While you are being treated with vinblastine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Vinblastine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. Other people living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the past several months. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.


Vinblastine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:


  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

  • Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.

  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.

  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.

  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.

  • Avoid contact sports or other situations where bruising or injury could occur.

If vinblastine accidentally seeps out of the vein into which it is injected, it may damage the skin and cause some scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.


Velban Side Effects


Along with their needed effects, medicines like vinblastine can sometimes cause unwanted effects such as blood problems, loss of hair, and other side effects. These and other effects are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.


Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More frequent
  • Cough or hoarseness accompanied by fever or chills

  • fever or chills

  • lower back or side pain accompanied by fever or chills

  • painful or difficult urination accompanied by fever or chills

Less common
  • Blood in urine or stools

  • pain or redness at place of injection

  • pinpoint red spots on skin

  • unusual bleeding or bruising

Rare
  • Black, tarry stools

Check with your doctor as soon as possible if any of the following side effects occur:


Less common
  • Joint pain

  • sores in mouth and on lips

  • swelling of feet or lower legs

Rare
  • Difficulty in walking

  • dizziness

  • double vision

  • drooping eyelids

  • headache

  • jaw pain

  • mental depression

  • numbness or tingling in fingers and toes

  • pain in fingers and toes

  • pain in testicles

  • weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common
  • Bone or muscle pain

  • nausea and vomiting

This medicine often causes a temporary loss of hair. After treatment with vinblastine has ended, or sometimes even during treatment, normal hair growth should return.


Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Velban side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Velban resources


  • Velban Side Effects (in more detail)
  • Velban Use in Pregnancy & Breastfeeding
  • Velban Drug Interactions
  • Velban Support Group
  • 0 Reviews for Velban - Add your own review/rating


  • Velban Concise Consumer Information (Cerner Multum)

  • Velban Monograph (AHFS DI)

  • Vinblastine Prescribing Information (FDA)

  • Vinblastine MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Velban with other medications


  • Breast Cancer
  • Cancer
  • Choriocarcinoma
  • Histiocytosis
  • Hodgkin's Lymphoma
  • Kaposi's Sarcoma
  • Lymphoma
  • Mycosis Fungoides
  • Testicular Cancer

Tuesday, 13 March 2012

Glucagon Emergency Kit


Generic Name: glucagon (Injection route)

GLOO-ka-gon

Commonly used brand name(s)

In the U.S.


  • Glucagen

  • Glucagen Diagnostic Kit

  • Glucagon

  • Glucagon Diagnostic Kit

  • Glucagon Emergency Kit

Available Dosage Forms:


  • Powder for Solution

Therapeutic Class: Glucose Regulation, Antihypoglycemic


Uses For Glucagon Emergency Kit


Glucagon belongs to the group of medicines called hormones. It is an emergency medicine used to treat severe hypoglycemia (low blood sugar) in patients with diabetes who have passed out or cannot take some form of sugar by mouth.


Glucagon is also used during x-ray tests of the stomach and bowels to improve test results by relaxing the muscles of the stomach and bowels. This also makes the testing more comfortable for the patient.


Glucagon also may be used for other conditions as determined by your doctor.


Glucagon is available only with your doctor's prescription.


Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, glucagon is used in certain patients with the following medical conditions or undergoing certain medical procedures:


  • Overdose of beta-adrenergic blocking medicines

  • Overdose of calcium channel blocking medicines

  • Removing food or an object stuck in the esophagus

  • Hysterosalpingography (x-ray examination of the uterus and fallopian tubes)

Before Using Glucagon Emergency Kit


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.


Geriatric


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of glucagon in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acenocoumarol

  • Anisindione

  • Dicumarol

  • Phenindione

  • Phenprocoumon

  • Warfarin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Diabetes mellitus—When glucagon is used for test or x-ray procedures in patients with diabetes that is well-controlled, a rise in blood sugar may occur; otherwise, glucagon is an important part of the management of diabetes because it is used to treat hypoglycemia (low blood sugar)

  • Insulinoma (tumors of the pancreas gland that make too much insulin) (or history of)—Blood sugar concentrations may decrease

  • Pheochromocytoma—Glucagon can cause high blood pressure

Proper Use of glucagon

This section provides information on the proper use of a number of products that contain glucagon. It may not be specific to Glucagon Emergency Kit. Please read with care.


Glucagon is an emergency medicine and must be used only as directed by your doctor. Make sure that you and a member of your family or a friend understand exactly when and how to use this medicine before it is needed .


Glucagon is packaged in a kit with a vial of powder containing the medicine and a syringe filled with liquid to mix with the medicine. Directions for mixing and injecting the medicine are in the package. Read the directions carefully and ask your health care professional for additional explanation, if necessary.


Glucagon should not be mixed after the expiration date printed on the kit and on one vial. Check the date regularly and replace the medicine before it expires. The printed expiration date does not apply after mixing, when any unused portion must be discarded.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • As an emergency treatment for hypoglycemia:
    • Adults and children weighing 20 kilograms (kg) (44 pounds) or more: 1 milligram (mg). The dose may be repeated after fifteen minutes if necessary.

    • Children weighing up to 20 kg (44 pounds): 0.5 mg or 20 to 30 micrograms (mcg) per kg (9.1 to 13.6 mcg per pound) of body weight. The dose may be repeated after fifteen minutes if necessary.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using Glucagon Emergency Kit


Patients with diabetes should be aware of the symptoms of hypoglycemia (low blood sugar). These symptoms may develop in a very short time and may result from:


  • using too much insulin (“insulin reaction”) or as a side effect from oral antidiabetic medicines.

  • delaying or missing a scheduled snack or meal.

  • sickness (especially with vomiting or diarrhea).

  • exercising more than usual.

Unless corrected, hypoglycemia will lead to unconsciousness, convulsions (seizures), and possibly death. Early symptoms of hypoglycemia include: anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, and unusual tiredness or weakness.


Symptoms of hypoglycemia can differ from person to person. It is important that you learn your own signs of low blood sugar so that you can treat it quickly. It is a good idea also to check your blood sugar to confirm that it is low.


You should know what to do if symptoms of low blood sugar occur. Eating or drinking something containing sugar when symptoms of low blood sugar first appear will usually prevent them from getting worse, and will probably make the use of glucagon unnecessary. Good sources of sugar include glucose tablets or gel, corn syrup, honey, sugar cubes or table sugar (dissolved in water), fruit juice, or nondiet soft drinks. If a meal is not scheduled soon (1 hour or less), you should also eat a light snack, such as crackers and cheese or half a sandwich or drink a glass of milk to keep your blood sugar from going down again. You should not eat hard candy or mints because the sugar will not get into your blood stream quickly enough. You also should not eat foods high in fat such as chocolate because the fat slows down the sugar entering the blood stream. After 10 to 20 minutes, check your blood sugar again to make sure it is not still too low.


Tell someone to take you to your doctor or to a hospital right away if the symptoms do not improve after eating or drinking a sweet food. Do not try to drive yourself.


If severe symptoms such as convulsions (seizures) or unconsciousness occur, the patient with diabetes should not be given anything to eat or drink. There is a chance that he or she could choke from not swallowing correctly. Glucagon should be administered and the patient's doctor should be called at once.


If it becomes necessary to inject glucagon, a family member or friend should know the following:


  • After the injection, turn the patient on his or her left side. Glucagon may cause some patients to vomit and this position will reduce the possibility of choking.

  • The patient should become conscious in less than 15 minutes after glucagon is injected, but if not, a second dose may be given. Get the patient to a doctor or to hospital emergency care as soon as possible because being unconscious too long can be harmful.

  • When the patient is conscious and can swallow, give him or her some form of sugar. Glucagon is not effective for much longer than 1½ hours and is used only until the patient is able to swallow. Fruit juice, corn syrup, honey, and sugar cubes or table sugar (dissolved in water) all work quickly. Then, if a snack or meal is not scheduled for an hour or more, the patient should also eat some crackers and cheese or half a sandwich, or drink a glass of milk. This will prevent hypoglycemia from occurring again before the next meal or snack.

  • The patient or caregiver should continue to monitor the patient's blood sugar. For about 3 to 4 hours after the patient regains consciousness, the blood sugar should be checked every hour.

  • If nausea and vomiting prevent the patient from swallowing some form of sugar for an hour after glucagon is given, medical help should be obtained.

Keep your doctor informed of any hypoglycemic episodes or use of glucagon even if the symptoms are successfully controlled and there seem to be no continuing problems. Complete information is necessary for the doctor to provide the best possible treatment of any condition.


Replace your supply of glucagon as soon as possible, in case another hypoglycemic episode occurs.


You should wear a medical identification (I.D.) bracelet or chain at all times. In addition, you should carry an I.D. card that lists your medical condition and medicines.


Glucagon Emergency Kit Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Less common
  • Dizziness

  • lightheadedness

  • trouble in breathing

Symptoms of overdose
  • Diarrhea

  • irregular heartbeat

  • loss of appetite

  • muscle cramps or pain

  • nausea (continuing)

  • vomiting (continuing)

  • weakness of arms, legs, and trunk (severe)

Check with your doctor as soon as possible if any of the following side effects occur:


Less common
  • Skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common or rare
  • Fast heartbeat

  • nausea

  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Glucagon Emergency side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Glucagon Emergency Kit resources


  • Glucagon Emergency Kit Side Effects (in more detail)
  • Glucagon Emergency Kit Use in Pregnancy & Breastfeeding
  • Glucagon Emergency Kit Drug Interactions
  • Glucagon Emergency Kit Support Group
  • 0 Reviews for Glucagon Emergency - Add your own review/rating


Compare Glucagon Emergency Kit with other medications


  • Diagnosis and Investigation
  • Hypoglycemia

Monday, 12 March 2012

Vivotif Berna Vaccine Delayed-Release Capsules


Pronunciation: TIE-foyd
Generic Name: Typhoid Vaccine Live
Brand Name: Vivotif Berna Vaccine


Vivotif Berna Vaccine Delayed-Release Capsules are used for:

Preventing typhoid fever in persons 6 years old and older who are at increased risk because they are traveling to an area where this infection is more common, have been in contact with infected individuals, or work in an environment that increases their risk (eg, lab work).


Vivotif Berna Vaccine Delayed-Release Capsules are a vaccine. It works by stimulating the body to produce antibodies against typhoid fever.


Do NOT use Vivotif Berna Vaccine Delayed-Release Capsules if:


  • you are allergic to any ingredient in Vivotif Berna Vaccine Delayed-Release Capsules

  • you have a current infection, cancer, fever, persistent vomiting or diarrhea, other stomach illness, or HIV or another condition that weakens the immune system

  • you are taking a sulfonamide (eg, sulfamethoxazole), another antibiotic (eg, penicillin), or a medicine that weakens the immune system (eg, cyclosporine, certain cancer medicines)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Vivotif Berna Vaccine Delayed-Release Capsules:


Some medical conditions may interact with Vivotif Berna Vaccine Delayed-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have an infection or fever, chronic diarrhea, an illness affecting the stomach or intestines, undiagnosed rectal hemorrhage, or persistent vomiting, or you are receiving chemotherapy or radiation therapy

Some MEDICINES MAY INTERACT with Vivotif Berna Vaccine Delayed-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Antibiotics (eg, penicillin), corticosteroids (eg, prednisone), immunosuppressants (eg, certain cancer medicines, cyclosporine), or sulfonamides (eg, sulfamethoxazole) because they may decrease Vivotif Berna Vaccine Delayed-Release Capsules's effectiveness

  • Proguanil because it may decrease Vivotif Berna Vaccine Delayed-Release Capsules's effectiveness. You should not take proguanil for at least 10 days after your last dose of Vivotif Berna Vaccine Delayed-Release Capsules. Discuss any questions with your doctor

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vivotif Berna Vaccine Delayed-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Vivotif Berna Vaccine Delayed-Release Capsules:


Use Vivotif Berna Vaccine Delayed-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Vivotif Berna Vaccine Delayed-Release Capsules with a cold or lukewarm drink 1 hour before or 2 hours after a meal.

  • Swallow Vivotif Berna Vaccine Delayed-Release Capsules whole. Do not break, crush, or chew before swallowing.

  • Do not take cracked or broken capsules.

  • Do not drink alcohol within 2 hours of taking Vivotif Berna Vaccine Delayed-Release Capsules.

  • Do not forget to skip a day between capsules. Take a capsule EVERY OTHER DAY as directed by your doctor.

  • For Vivotif Berna Vaccine Delayed-Release Capsules to be effective, you must complete all 4 doses at least 1 week before exposure to typhoid fever.

  • If you miss a dose of Vivotif Berna Vaccine Delayed-Release Capsules, take it as soon as possible. If you do not remember until the next day, take the dose as soon as possible and reschedule your doses from that day.

Ask your health care provider any questions you may have about how to use Vivotif Berna Vaccine Delayed-Release Capsules.



Important safety information:


  • Notify your doctor if you experience diarrhea, vomiting, or flu-like symptoms after taking Vivotif Berna Vaccine Delayed-Release Capsules.

  • This vaccine helps prevent typhoid fever, but does not provide 100% protection. It is important to also avoid infected people, food, and water.

  • It is recommended that you receive another 4 doses of Vivotif Berna Vaccine Delayed-Release Capsules every 5 years if you continue to be exposed to typhoid fever.

  • Vivotif Berna Vaccine Delayed-Release Capsules are not recommended for use in CHILDREN younger than 6 years of age; safety and effectiveness in these children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vivotif Berna Vaccine Delayed-Release Capsules during pregnancy. It is not known if Vivotif Berna Vaccine Delayed-Release Capsules are found in breast milk. If you are or will be breast-feeding while you use Vivotif Berna Vaccine Delayed-Release Capsules, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Vivotif Berna Vaccine Delayed-Release Capsules:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Diarrhea; fever; headache; muscle pain; nausea; stomach cramps or pain; vomiting.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty swallowing; unusual hoarseness.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Vivotif Berna side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Vivotif Berna Vaccine Delayed-Release Capsules:

Store Vivotif Berna Vaccine Delayed-Release Capsules in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), at all times. Do not freeze. Keep Vivotif Berna Vaccine Delayed-Release Capsules out of the reach of children and away from pets.


General information:


  • If you have any questions about Vivotif Berna Vaccine Delayed-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.

  • Vivotif Berna Vaccine Delayed-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Vivotif Berna Vaccine Delayed-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Vivotif Berna Vaccine resources


  • Vivotif Berna Vaccine Side Effects (in more detail)
  • Vivotif Berna Vaccine Use in Pregnancy & Breastfeeding
  • Vivotif Berna Vaccine Drug Interactions
  • Vivotif Berna Vaccine Support Group
  • 0 Reviews for Vivotif Berna - Add your own review/rating


Compare Vivotif Berna Vaccine with other medications


  • Typhoid Prophylaxis

Thursday, 8 March 2012

Humulin L


Generic Name: insulin zinc (IN suh lin ZINK)

Brand Names: Humulin L, Iletin Lente, Insulin Lente Pork, Novolin L


What is Humulin L (insulin zinc)?

Insulin is a hormone naturally produced by the pancreas. Insulin enables the body to use the sugar in food as a source of energy. When the body does not produce enough insulin, or when the insulin produced by the body is not effective enough, the condition is called diabetes mellitus. This condition allows sugar levels in the blood to become very high. Diabetics must use man-made insulin or insulin that comes from pigs (which is very similar to human insulin) to lower these high blood sugar levels.


Insulin zinc is used is used in the treatment of diabetes mellitus.


Insulin zinc may also be used for purposes other than those listed in this medication guide.


What is the most important information I should know about Humulin L (insulin zinc)?


Know the signs and symptoms of low blood sugar (hypoglycemia), which include shaking; nausea; headache; drowsiness; weakness; dizziness; fast heartbeat; sweating; pale, cool skin; anxiety; and difficulty concentrating. Carry a piece of candy or glucose tablets with you to treat episodes of low blood sugar.


Follow any diet and exercise plan that you have developed with your doctor or nurse. Changes in what you eat or how much you exercise can change the amount of insulin that you need to control your blood sugar levels.


Ask your doctor or nurse what to do if you are sick with a cold, flu, or fever. These illnesses may change your insulin requirements.


Do not change the brand of insulin zinc or syringe that you are using without first talking to your doctor or pharmacist. Some brands of insulin and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another.


What should I discuss with my healthcare provider before using Humulin L (insulin zinc)?


Do not use insulin zinc if you are allergic to insulin or if you have intolerance to a certain insulin zinc product.


Before using insulin, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medications, including vitamins, minerals, and herbal supplements.


Before using insulin zinc, tell your doctor if you have kidney or liver disease. You may require a dosage adjustment or special monitoring during treatment.

Most insulins can be used during pregnancy and breast-feeding. They are not expected to be harmful to an unborn baby. It is very important to control blood sugar levels during pregnancy and breast-feeding and insulin is often chosen as the treatment. Some types of insulin may be better than others for use during pregnancy and breast-feeding. Talk to your doctor about the use of insulin during pregnancy and breast-feeding.


How should I use Humulin L (insulin zinc)?


Use insulin zinc exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.


If insulin zinc has been stored in the refrigerator, it can be warmed to room temperature before use. Also, roll it slightly between your hands to be sure that it is mixed. Never shake an insulin zinc suspension vigorously.


If you are mixing different types of insulins in the same syringe, follow your doctor's directions and always draw up the different insulins in the same order (usually the clear insulin first). This may help prevent a dosage error. Do not mix different insulins in the same syringe unless specifically directed to do so by your doctor. Some types of insulins should not be mixed.


Do not use any insulin that is discolored, looks thick, has particles in it, or looks different from previous bottles, cartridges, or pens of insulin zinc.

Change injection sites as directed by your doctor. Usually, you should not inject within 1 inch of the same site within 1 month.


Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture-resistant disposal container.


Do not change the insulin strength (e.g., U-100) or insulin type (e.g., zinc, regular, lispro, etc.) unless your doctor recommends a change for you.


Do not change the brand of insulin zinc or syringe that you are using without first talking to your doctor or pharmacist. Some brands of insulin zinc and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another.


Follow any diet and exercise plan that you have developed with your doctor or nurse. Changes in what you eat or how much you exercise can change the amount of insulin that you need to control your blood sugar levels.


Ask your doctor or nurse what to do if you are sick with a cold, flu, or fever. These illnesses may change your insulin requirements.


Your healthcare provider may recommend regular monitoring of blood sugar levels with blood or urine tests.


Wear some type of medical identification bracelet, necklace, or other alert tag to inform others that you have diabetes and that you require insulin in the case of an emergency.


Proper foot care, eye care, dental care, and overall proper health care are important for people with diabetes. Visit your doctor, dentist, eye doctor, and other heath care practitioners as recommended by your doctor.


Store unopened vials of insulin zinc the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius), in the original carton. Do not store insulin zinc in the freezer and do not allow it to freeze. Do not use insulin zinc if it has been frozen. Throw away any expired insulin zinc. Vials of insulin zinc can be kept unrefrigerated for up to 28 days, but should not be exposed to excessive heat or sunlight.

Once punctured, the insulin vial in use, whether stored in the refrigerator or at room temperature, must be used within 28 days. Throw away any unused insulin 28 days after the vial is first punctured.


What happens if I miss a dose?


Follow your doctor's directions if you miss a dose of insulin. To prevent missed doses, be sure to always have enough insulin on hand, especially if you are going on vacation.


What happens if I overdose?


Seek emergency medical attention if an overdose is suspected.

Symptoms of an insulin overdose reflect very low blood sugar levels and include headache, irregular heartbeat, increased heart rate or pulse, sweating, tremor, nausea, increased hunger, and anxiety.


What should I avoid while using Humulin L (insulin zinc)?


Do not use alcohol without first talking to your doctor. It lowers blood sugar, and you may experience dangerously low blood sugar levels.

Follow any diet and exercise plan that you have developed with your doctor or nurse. Changes in what you eat or how much you exercise can change the amount of insulin you need to control your blood sugar levels.


Humulin L (insulin zinc) side effects


Rarely, people have allergic reactions to insulin. Seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

The side effects of insulin therapy result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency.


Low blood sugar may occur when too much insulin is used; when meals are missed or delayed; if you exercise more than usual; during illness, especially with vomiting or diarrhea; if you take other medications; after drinking alcohol; and in other situations.


Hypoglycemia, or low blood sugar, has the following symptoms: shaking; nausea; headache; drowsiness; weakness; dizziness; fast heartbeat; sweating; pale, cool skin; anxiety; and difficulty concentrating.


Keep sugary candy, fruit juice, or glucose tablets on hand to treat episodes of low blood sugar.


Increased blood sugar may occur if not enough insulin is used, if you eat significantly more food then usual, if you exercise less than usual, if you take other medications, if you have a fever or other illness, and in other situations.


Hyperglycemia, or high blood sugar, has the following symptoms: increased thirst, increased hunger, and increased urination.


Monitor your blood sugar levels and ask your doctor how to adjust your insulin doses if your blood sugar levels are too high.


Side effects may also occur at the site of injection. If the area becomes thickened, hard, or pitted, talk to your doctor before injecting at that site again.


Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.


What other drugs will affect Humulin L (insulin zinc)?


Many drugs can interact with insulin or affect blood sugar levels. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor or pharmacist during treatment with insulin.

More Humulin L resources


  • Humulin L Side Effects (in more detail)
  • Humulin L Use in Pregnancy & Breastfeeding
  • Humulin L Drug Interactions
  • Humulin L Support Group
  • 0 Reviews for Humulin L - Add your own review/rating


  • Humulin L Prescribing Information (FDA)



Compare Humulin L with other medications


  • Diabetes, Type 1
  • Diabetes, Type 2
  • Gestational Diabetes


Where can I get more information?


  • Your pharmacist has additional information about insulin zinc written for health professionals that you may read.

What does my medication look like?


Insulin zinc is available under the brand names Humulin L, Novolin L, Iletin II Lente, and Insulin Lente Pork. The insulin should be a clear, colorless or evenly colored liquid after it is gently rolled or shaken. Do not use it if it appears to be thick, looks sticky, has particles in it, or looks different from previous bottles of insulin that you have had. Always use the same brand unless your doctor approves a change. Ask your pharmacist, nurse, or doctor any questions you have about this medication.



  • Humulin L-10 mL vials




  • Novolin L-10 mL vials




  • Iletin II Lente-10 mL vials




  • Insulin Lente Pork-10 mL vials



See also: Humulin L side effects (in more detail)


Sunday, 4 March 2012

Sabril


Generic Name: vigabatrin (Oral route)

vye-GA-ba-trin

Oral route(Tablet;Solution)

Vigabatrin causes permanent vision loss which may occur at any time during therapy and the risk increases with total dose and duration of use. Periodic vision testing is required for patients receiving vigabatrin therapy. Vigabatrin should not be used concomitantly with other drugs associated with adverse ophthalmic effects or in patients at high risk for other types of irreversible vision damage. Vigabatrin is only available through a special restricted distribution program .



Commonly used brand name(s)

In the U.S.


  • Sabril

Available Dosage Forms:


  • Tablet

  • Powder for Solution

  • Powder

Therapeutic Class: Anticonvulsant


Pharmacologic Class: Gamma Aminobutyric Acid Transaminase Inhibitor


Chemical Class: Gamma Aminobutyric Acid (class)


Uses For Sabril


Vigabatrin is used alone or together with other medicines to control certain types of seizures (convulsions) in the treatment of epilepsy. This medicine is used in patients with seizures who have already been treated with other medicines that did not work well.


Vigabatrin is an anticonvulsant. It increases the amount of the chemical called gamma amino butyric acid (GABA) in the brain. It is thought that epileptic seizures are the result of low levels of GABA. By increasing the amount of GABA, vigabatrin reduces the likelihood of an epileptic seizure.


This medicine is available only with your doctor's prescription.


Before Using Sabril


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of vigabatrin oral solution to treat infantile spasms in children and infants 1 month to 2 years of age.


Appropriate studies have not been performed on the relationship of age to the effects of vigabatrin tablets in children and teenagers younger than 16 years of age with complex partial seizures. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of valproate sodium injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving vigabatrin.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Carbamazepine

  • Ketorolac

  • Naproxen

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Fosphenytoin

  • Ginkgo

  • Phenytoin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Anemia or

  • Depression, history of or

  • Eye or vision problems or

  • Mental illness, history of—Use with caution. May make these conditions worse.

  • Kidney disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

Proper Use of Sabril


Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.


It is very important that you understand the requirements of the SHARE program, and become familiar with Sabril® Medication Guide. Ask your doctor or pharmacist before starting treatment with vigabatrin.


You may take this medicine with or without food.


To use the oral solution:


  • Open the packet and empty the contents into an empty cup.

  • Dissolve it with 10 milliliters (mL) of cold or room temperature water.

  • Measure the dose with an oral syringe that comes with the package.

Vigabatrin may be used together with other seizure medicines. Keep using all of your medicines unless your doctor tells you to stop.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (solution):
    • For infantile spasms:
      • Children and infants 1 month to 2 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is 50 milligrams (mg) per kilogram (kg) of body weight per day, given in smaller doses two times a day. Your doctor may adjust the dose as needed up to a maximum dose of 150 mg per kg of body weight per day.

      • Infants up to 1 month—Use and dose must be determined by your doctor.



  • For oral dosage form (tablets):
    • For seizures:
      • Adults—At first, 500 milligrams (mg) two times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg a day.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Sabril


It is very important that your doctor check your or your child's progress at regular visits to allow for changes in the dose and to check for any unwanted effects.


It is important to tell your doctor if you become pregnant. Your doctor may want you to join a pregnancy registry for patients taking a seizure medicine.


This medicine may increase your risk of permanent vision loss. Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. It is very important that your ophthalmologist (eye doctor) check your child's or your eyes approximately every 3 months for any visual problems.


Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests (e.g., magnetic resonance imaging or MRI).


This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor right away.


This medicine may cause some people to become drowsy, sleepy, or weak than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are drowsy or not alert.


Check with your doctor right away if you or your child are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.


Tell your doctor if you or your child have increased weight or swelling in the hands, ankles, or feet while taking this medicine.


Do not suddenly stop taking this medicine without checking first with your doctor. Your doctor may want to gradually reduce the amount you are using before stopping it completely. Stopping this medicine suddenly may cause seizures.


Sabril Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Blue-yellow color blindness

  • blurred vision

  • decreased vision or other vision changes

  • eye pain

  • increase in seizures

  • loss of memory

  • problems with memory

Less common or rare
  • Uncontrolled rolling eye movements

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Mood or mental changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Abdominal or stomach pain

  • abnormal coordination

  • agitation

  • anxiety

  • burning, tingling, or prickly sensations

  • clumsiness

  • confusion

  • constipation

  • diarrhea

  • dizziness

  • double vision or seeing double

  • drowsiness

  • increased movement

  • joint pain

  • mental depression

  • restlessness

  • shakiness

  • sleepiness or unusual drowsiness

  • trembling

  • tremor

  • trouble sitting still

  • unsteadiness

Less common
  • Aggression

  • headache

  • increased saliva

  • muscle weakness

  • nausea

  • poor concentration

  • sleeplessness

  • speech disorder

  • thinking abnormal

  • trouble sleeping

  • unable to sleep

  • vomiting

  • weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Sabril side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Sabril resources


  • Sabril Side Effects (in more detail)
  • Sabril Use in Pregnancy & Breastfeeding
  • Sabril Drug Interactions
  • Sabril Support Group
  • 0 Reviews for Sabril - Add your own review/rating


  • Sabril Prescribing Information (FDA)

  • Sabril MedFacts Consumer Leaflet (Wolters Kluwer)

  • Sabril Consumer Overview

  • Vigabatrin Professional Patient Advice (Wolters Kluwer)



Compare Sabril with other medications


  • Epilepsy
  • Seizure Prevention
  • Seizures

Thursday, 1 March 2012

Phena-Plus


Pronunciation: KLOR-fen-IR-a-meen/FEN-il-EF-rin/pir-IL-a-meen
Generic Name: Chlorpheniramine/Phenylephrine/Pyrilamine
Brand Name: Phena-Plus


Phena-Plus is used for:

Relieving symptoms of sinus congestion, pressure, runny nose, and sneezing due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.


Phena-Plus is an antihistamine and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, which relieves congestion and pressure.


Do NOT use Phena-Plus if:


  • you are allergic to any ingredient in Phena-Plus

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you take droxidopa, sodium oxybate (GHB), or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Phena-Plus:


Some medical conditions may interact with Phena-Plus. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of adrenal gland problems (eg, adrenal gland tumor); heart problems (eg, cor pulmonale; fast, slow, or irregular heartbeat; heart disease); high blood pressure; diabetes; blood vessel problems; stroke; glaucoma or increased pressure in the eye; seizures; or thyroid problems

  • if you have a history of asthma or other breathing problems, chronic cough, lung problems (eg, chronic bronchitis, emphysema), chronic obstructive pulmonary disease (COPD), or sleep apnea

  • if you have a blockage of your bladder, stomach, or bowels; ulcers; trouble sleeping; trouble urinating; an enlarged prostate or other prostate problems

Some MEDICINES MAY INTERACT with Phena-Plus. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, linezolid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Phena-Plus's side effects

  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Phena-Plus

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Phena-Plus

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phena-Plus may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Phena-Plus:


Use Phena-Plus as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Phena-Plus by mouth with or without food.

  • If you miss a dose of Phena-Plus and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Phena-Plus.



Important safety information:


  • Phena-Plus may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Phena-Plus with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Phena-Plus; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

  • Do not take diet or appetite control medicines while you are taking Phena-Plus without checking with your doctor.

  • Before you start any new medicine, check the label to see if it has a decongestant or antihistamine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.

  • Phena-Plus may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Phena-Plus. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Phena-Plus may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Phena-Plus for a few days before the tests.

  • Tell your doctor or dentist that you take Phena-Plus before you receive any medical or dental care, emergency care, or surgery.

  • Use Phena-Plus with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, excitability, low blood pressure, and trouble urinating.

  • Caution is advised when using Phena-Plus in CHILDREN; they may be more sensitive to its effects, especially excitability.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Phena-Plus while you are pregnant. Phena-Plus may be found in breast milk. Do not breast-feed while taking Phena-Plus.


Possible side effects of Phena-Plus:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mood or mental changes; persistent trouble sleeping; restlessness; seizures; severe dizziness, drowsiness, lightheadedness, or headache; tremor.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Phena-Plus side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular breathing; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Phena-Plus:

Store Phena-Plus at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phena-Plus out of the reach of children and away from pets.


General information:


  • If you have any questions about Phena-Plus, please talk with your doctor, pharmacist, or other health care provider.

  • Phena-Plus is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Phena-Plus. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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