Dolokid's

Dolokid's may be available in the countries listed below.

Ingredient matches for Dolokid's

Ibuprofen

Ibuprofen is reported as an ingredient of Dolokid's in the following countries:

• Peru

International Drug Name Search

Copharlan

Copharlan may be available in the countries listed below.

Ingredient matches for Copharlan

Tetracycline

Tetracycline hydrochloride (a derivative of Tetracycline) is reported as an ingredient of Copharlan in the following countries:

• Ethiopia

International Drug Name Search

Chlorure de Calcium Renaudin

Chlorure de Calcium Renaudin may be available in the countries listed below.

Ingredient matches for Chlorure de Calcium Renaudin

Calcium Chloride

Calcium Chloride hexahydrate (a derivative of Calcium Chloride) is reported as an ingredient of Chlorure de Calcium Renaudin in the following countries:

• France

International Drug Name Search

Romet

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Romet

Ormetoprim

Ormetoprim is reported as an ingredient of Romet in the following countries:

• United States

Repirinast

Repirinast is reported as an ingredient of Romet in the following countries:

• Japan

Sulfadimethoxine

Sulfadimethoxine is reported as an ingredient of Romet in the following countries:

• United States

International Drug Name Search

Ispidon

Ispidon may be available in the countries listed below.

Ingredient matches for Ispidon

Risperidone

Risperidone is reported as an ingredient of Ispidon in the following countries:

• Peru

International Drug Name Search

Flanizol

Flanizol may be available in the countries listed below.

Ingredient matches for Flanizol

Metronidazole

Metronidazole is reported as an ingredient of Flanizol in the following countries:

• Bahrain


• Iraq


• Jordan


• Libya


• Qatar


• Saudi Arabia


• Sudan


• United Arab Emirates


• Yemen

International Drug Name Search

Pentoxifyllin acis

Pentoxifyllin acis may be available in the countries listed below.

Ingredient matches for Pentoxifyllin acis

Pentoxifylline

Pentoxifylline is reported as an ingredient of Pentoxifyllin acis in the following countries:

• Germany

International Drug Name Search

Claritromicina Baldacci

Claritromicina Baldacci may be available in the countries listed below.

Ingredient matches for Claritromicina Baldacci

Clarithromycin

Clarithromycin is reported as an ingredient of Claritromicina Baldacci in the following countries:

• Portugal

International Drug Name Search

Halop

Halop may be available in the countries listed below.

Ingredient matches for Halop

Haloperidol

Haloperidol is reported as an ingredient of Halop in the following countries:

• Bangladesh

International Drug Name Search

Temazepam AccordHealthcare

Temazepam AccordHealthcare may be available in the countries listed below.

Ingredient matches for Temazepam AccordHealthcare

Temazepam

Temazepam is reported as an ingredient of Temazepam AccordHealthcare in the following countries:

• Netherlands

International Drug Name Search

Acnotin

Acnotin may be available in the countries listed below.

Ingredient matches for Acnotin

Isotretinoin

Isotretinoin is reported as an ingredient of Acnotin in the following countries:

• Ecuador


• Peru

International Drug Name Search

Prothazin

Prothazin may be available in the countries listed below.

Ingredient matches for Prothazin

Promethazine

Promethazine hydrochloride (a derivative of Promethazine) is reported as an ingredient of Prothazin in the following countries:

• Czech Republic


• Germany


• Slovakia

International Drug Name Search

Cortamine

Cortamine may be available in the countries listed below.

Ingredient matches for Cortamine

Betamethasone

Betamethasone is reported as an ingredient of Cortamine in the following countries:

• Indonesia

Dexchlorpheniramine

Dexchlorpheniramine maleate (a derivative of Dexchlorpheniramine) is reported as an ingredient of Cortamine in the following countries:

• Indonesia

International Drug Name Search

Succicaptal

Succicaptal may be available in the countries listed below.

Ingredient matches for Succicaptal

Succimer

Succimer is reported as an ingredient of Succicaptal in the following countries:

• France

International Drug Name Search

Oxy 10 Balance

Generic Name: benzoyl peroxide topical (BEN zoyl per OX ide)

Brand Names: Acne Treatment, Acne-Clear, Benzac AC, Benzac W, Benzashave 10, Benzashave 5, BenzEFoam, Benziq, Benziq Wash, BPO Foaming Cloths, Brevoxyl, Brevoxyl Acne Wash Kit, Brevoxyl-4 Creamy Wash Complete Pack, Brevoxyl-8 Creamy Wash Complete Pack, Breze, Clearplex, Clearskin, Clinac BPO, Desquam-E, Desquam-X 10, Desquam-X 5, Desquam-X Wash, Fostex Bar 10%, Fostex Gel 10%, Fostex Wash 10%, Inova, Lavoclen-4, Lavoclen-8, Loroxide, NeoBenz Micro, Neutrogena Acne Mask, Neutrogena On Spot Acne Treatment, Oscion, Oscion Cleanser, Oxy 10 Balance, Oxy Balance, Oxy Daily Wash Chill Factor, Oxy-10, Pacnex, PanOxyl, Panoxyl 10, Panoxyl 5, Panoxyl Aqua Gel, PanOxyl Maximum Strength Foaming Acne Wash, Persa-Gel, Seba-Gel, SoluCLENZ Rx, Triaz, Triaz Cleanser, Zaclir

What is Oxy 10 Balance (benzoyl peroxide topical)?

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect, which allows excess oils and dirt to be easily washed away from the skin.

Benzoyl peroxide topical (for the skin) is used to treat acne.

Benzoyl peroxide topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Oxy 10 Balance (benzoyl peroxide topical)?

There are many brands and forms of benzoyl peroxide available and not all brands are listed on this leaflet.

Do not use benzoyl peroxide topical while you are also using tretinoin (Altinac, Avita, Renova, Retin-A, Tretin-X). Using these medications together could cause severe skin irritation.

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water. Do not use benzoyl peroxide topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using benzoyl peroxide topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Benzoyl peroxide may bleach hair or fabrics. Avoid allowing this medication to come into contact with your hair or clothing.

It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

What should I discuss with my healthcare provider before using Oxy 10 Balance (benzoyl peroxide topical)?

Do not use benzoyl peroxide topical while you are also using tretinoin (Altinac, Avita, Renova, Retin-A, Tretin-X). Using these medications together could cause severe skin irritation. FDA pregnancy category C. It is not known whether benzoyl peroxide topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether benzoyl peroxide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Oxy 10 Balance (benzoyl peroxide topical)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Wash your hands before and after applying this medication. Shake the lotion well just before each use.

Clean and pat dry the skin to be treated. Apply benzoyl peroxide in a thin layer and rub in gently.

Do not cover the treated skin area unless your doctor has told you to.

Benzoyl peroxide topical is usually applied one to three times daily. Follow your doctor's instructions.

Benzoyl peroxide may bleach hair or fabrics. Avoid allowing this medication to come into contact with your hair or clothing.

It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Oxy 10 Balance (benzoyl peroxide topical)?

Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water. Do not use benzoyl peroxide topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using benzoyl peroxide topical on wounds or on areas of eczema. Wait until these conditions have healed before using this medication.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Avoid using sunscreen containing PABA on the same skin treated with benzoyl peroxide, or skin discoloration may occur.

Oxy 10 Balance (benzoyl peroxide topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using benzoyl peroxide and call your doctor at once if you have severe stinging or burning of your skin.

Less serious side effects may include:

• 
  

  mild stinging or burning;

  
  


• 
  

  itching or tingly feeling;

  
  


• 
  

  skin dryness, peeling, or flaking; or

  
  


• 
  

  redness or other irritation.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Oxy 10 Balance (benzoyl peroxide topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied benzoyl peroxide topical. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Oxy 10 Balance resources

• Oxy 10 Balance Side Effects (in more detail)
• Oxy 10 Balance Use in Pregnancy & Breastfeeding
• Oxy 10 Balance Drug Interactions
• Oxy 10 Balance Support Group
• 0 Reviews for Oxy0 Balance - Add your own review/rating

• Acne Treatment Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• BenzEFoam Foam MedFacts Consumer Leaflet (Wolters Kluwer)


• Benzac Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Benzac AC Wash MedFacts Consumer Leaflet (Wolters Kluwer)


• Benzefoam Prescribing Information (FDA)


• Benzefoam Ultra Prescribing Information (FDA)


• Brevoxyl Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Brevoxyl Creamy Wash Prescribing Information (FDA)


• Desquam-X Wash Prescribing Information (FDA)


• Inova Pads MedFacts Consumer Leaflet (Wolters Kluwer)


• NeoBenz Micro Wash Plus Pack Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Neobenz Micro SD Prescribing Information (FDA)


• Neobenz Micro Wash Plus Pack Prescribing Information (FDA)


• Oxy Balance Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Pacnex LP Prescribing Information (FDA)


• PanOxyl Bar MedFacts Consumer Leaflet (Wolters Kluwer)


• Triaz Cloths MedFacts Consumer Leaflet (Wolters Kluwer)


• Triazolam Monograph (AHFS DI)

Compare Oxy 10 Balance with other medications

• Acne
• Perioral Dermatitis

Where can I get more information?

• Your pharmacist can provide more information about benzoyl peroxide topical.

See also: Oxy0 Balance side effects (in more detail)

Oxaliplatin Teva

Oxaliplatin Teva may be available in the countries listed below.

Ingredient matches for Oxaliplatin Teva

Oxaliplatin

Oxaliplatin is reported as an ingredient of Oxaliplatin Teva in the following countries:

• Austria


• Croatia (Hrvatska)


• Greece


• Latvia


• Sweden

International Drug Name Search

Pioglitazone

In the US, Pioglitazone (pioglitazone systemic) is a member of the drug class thiazolidinediones and is used to treat Diabetes - Type 2 and Nonalcoholic Fatty Liver Disease.

US matches:

• Pioglitazone


• Pioglitazone/Glimepiride


• Pioglitazone/Metformin


• Pioglitazone/Metformin Extended-Release Tablets


• Pioglitazone and glimepiride


• Pioglitazone and metformin


• Pioglitazone Hydrochloride


• Pioglitazone Hydrochloride/Glimepiride


• Pioglitazone Hydrochloride/Metformin Hydrochloride

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

A10BG03

CAS registry number (Chemical Abstracts Service)

0111025-46-8

Chemical Formula

C19-H20-N2-O3-S

Molecular Weight

356

Therapeutic Category

Oral antidiabetic agent, insulin sensitizer, thiazolidinedione (glitazone)

Chemical Names

(+/-)-5-[p-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione (WHO)

2,4-Thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, (+-)-

2,4-Thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, monohydrochloride, (+-)- (USAN)

Foreign Names

• Pioglitazonum (Latin)
• Pioglitazon (German)
• Pioglitazone (French)
• Pioglitazona (Spanish)

Generic Names

• Pioglitazone (OS: BAN, DCF)
• AD 4833 (IS: Takeda)
• U 72107 E (IS: Upjohn, Takeda)
• Pioglitazone Hydrochloride (OS: USAN)
• U 72107 A (IS: Upjohn)

Brand Names

• Actos
  Abbott, Venezuela; APM, Tunisia; Eli Lilly, South Africa; Takeda, Indonesia; Takeda Europe, Austria



• Actose
  Unimed & Unihealth, Bangladesh



• Adpas
  General Pharma, Bangladesh



• Apo-Pioglitazone
  Apotex, Canada



• Cipla-Pioglitazone
  Cipla Medpro, South Africa



• Diabestat
  ABL, Peru



• Diaglit
  Beximco, Bangladesh; Beximco, Myanmar



• Dianorm
  General Pharma, Bangladesh



• Glitazon
  Ibn Sina, Bangladesh



• Glitter-M (Pioglitazone and Metformin)
  Ind-Swift, India



• Glucozon
  Aristopharma, Bangladesh



• Glustin
  Eli Lilly, Oman; Lilly, Bahrain; Takeda, Luxembourg



• G-Tase
  Unichem, India



• Inzudil
  Mediline, Peru



• Opam
  Wockhardt, India



• Peegee
  Jayson, Bangladesh



• Piagtos
  Teriak, Tunisia



• Piodar
  Incepta, Bangladesh



• Pioglin
  Renata, Bangladesh



• Piol
  Opsonin, Bangladesh



• Piolit
  Alco, Bangladesh



• Poizena
  Drug International, Bangladesh



• Prialta
  OEP, Philippines



• Tiazac
  Biopharm, Chile



• Tos
  Square, Bangladesh



• Zactos
  Lilly, Mexico



• Actoplus Met (Pioglitazone and Metformin)
  Takeda, United States



• Actos
  Abbott, Argentina; Abbott, Ecuador; Abbott, Peru; Arab Pharmaceutical Manufacturing, Bahrain; Arab Pharmaceutical Manufacturing Co. LTD. - APM, Oman; Eli Lilly, Canada; Farmaserv, Greece; Lilly, Netherlands Antilles; Lilly, Australia; Lilly, Aruba; Lilly, Barbados; Lilly, Belgium; Lilly, Bermuda; Lilly, Bahamas; Lilly, Costa Rica; Lilly, Spain; Lilly, Finland; Lilly, Guatemala; Lilly, Honduras; Lilly, Haiti; Lilly, Jamaica; Lilly, Cayman Islands; Lilly, Nicaragua; Lilly, New Zealand; Lilly, Panama; Lilly, Portugal; Lilly, Romania; Lilly, Russian Federation; Lilly, Slovenia; Lilly, El Salvador; Lilly, Trinidad & Tobago; Takeda, Czech Republic; Takeda, Germany; Takeda, Denmark; Takeda, France; Takeda, United Kingdom; Takeda, Greece; Takeda, Hong Kong; Takeda, Hungary; Takeda, Ireland; Takeda, Iceland; Takeda, Japan; Takeda, Luxembourg; Takeda, Philippines; Takeda, Slovakia; Takeda, Thailand; Takeda, Taiwan; Takeda, United States; Takeda Europe, Austria; Takeda Europe R&D, Netherlands; Takeda Europe R&D-GB, Italy; Takeda Pharma, Switzerland



• Cereluc
  Beta, Argentina



• CO Pioglitazone
  Cobalt, Canada



• Competact (Pioglitazone and Metformin)
  Lilly, Spain; Lilly, Finland; Takeda, Germany; Takeda, France; Takeda, United Kingdom; Takeda, Ireland; Takeda, Italy; Takeda, Norway; Takeda Europe, Austria; Takeda Europe R&D, Netherlands; Takeda Pharma, Switzerland



• Deculin
  Dexa Medica, Indonesia



• Diabestat
  Andromaco, Chile



• Diavista
  Dr Reddys, Sri Lanka



• Dopili
  Domesco, Vietnam



• Dropia
  Sanovel, Turkey



• Duetact (Pioglitazone and Glimepiride)
  Takeda, United States



• Gen-Pioglitazone
  Genpharm, Canada



• Glifix
  Bilim, Turkey



• Glizone
  Zydus Cadila, India; Zydus Cadila, Myanmar



• Glucemin
  Biogen, Colombia



• Glustin
  Takeda, Spain



• Higlucem
  Lazar, Argentina



• Pioglar
  Ranbaxy, Sri Lanka



• Pioglit
  Phoenix, Argentina; Sun, Sri Lanka; Sun, Myanmar



• Pioglitazone Stada
  Stada, Vietnam



• Piogtan
  Eczacibasi, Turkey



• Pionorm
  Micro Labs, Myanmar



• Pio-Q Plus (Pioglitazone and Metformin HCl)
  Q-Check, India



• Pio-Q
  Q-Check, India



• Pioz
  USV, Myanmar



• PMS-Pioglitazone
  Pharmascience, Canada



• PrandiMet (Pioglitazone and Metformin)
  Novo Nordisk, United States



• ratio-Pioglitazone
  ratiopharm, Canada



• Sandoz Pioglitazone
  Sandoz, Canada



• Tademact (Pioglitazone and Glimepiride)
  Takeda, Germany



• Tandemact (Pioglitazone and Glimepiride)
  Takeda, Germany; Takeda Europe, Austria



• Zypi
  Schwarz, Philippines

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
IS	Inofficial Synonym
OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Meloxil

Meloxil may be available in the countries listed below.

Ingredient matches for Meloxil

Meloxicam

Meloxicam is reported as an ingredient of Meloxil in the following countries:

• Dominican Republic


• Greece

International Drug Name Search

Copper Sulfphate Ointment

Copper Sulfphate Ointment may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Copper Sulfphate Ointment

Copper Sulphate

Copper Sulphate pentahydrate (a derivative of Copper Sulphate) is reported as an ingredient of Copper Sulfphate Ointment in the following countries:

• New Zealand

International Drug Name Search

Cloxacilline

Cloxacilline may be available in the countries listed below.

Ingredient matches for Cloxacilline

Cloxacillin

Cloxacilline (DCF) is known as Cloxacillin in the US.

International Drug Name Search

Glossary

DCF	Dénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Lipnol

Lipnol may be available in the countries listed below.

Ingredient matches for Lipnol

Terbinafine

Terbinafine hydrochloride (a derivative of Terbinafine) is reported as an ingredient of Lipnol in the following countries:

• Japan

International Drug Name Search

Secnol

Secnol may be available in the countries listed below.

Ingredient matches for Secnol

Secnidazole

Secnidazole is reported as an ingredient of Secnol in the following countries:

• France


• Luxembourg

International Drug Name Search

Gulf War Syndrome Medications

There are currently no drugs listed for "Gulf War Syndrome". See Organophosphate Poisoning.

Definition of Gulf War Syndrome:

Gulf War Syndrome is a cluster of health problems experienced by U.S. military personnel after serving in the Persian Gulf conflict of 1991; includes fatigue, musculoskeletal pain, headaches, dyspnea, memory loss, and diarrhea; thought to be related to exposure to low levels of neurotoxins, including sarin, pesticides, and pyridostigmine bromide (the latter supplied to troops as a protective anti-toxin).

Drug List:

Zeptrigen

Zeptrigen may be available in the countries listed below.

Ingredient matches for Zeptrigen

Ceftazidime

Ceftazidime is reported as an ingredient of Zeptrigen in the following countries:

• Philippines

International Drug Name Search

Sulphatrim

Sulphatrim may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Sulphatrim

Sulfadiazine

Sulfadiazine is reported as an ingredient of Sulphatrim in the following countries:

• Australia

Sulfamethoxazole

Sulfamethoxazole is reported as an ingredient of Sulphatrim in the following countries:

• Bangladesh

Trimethoprim

Trimethoprim is reported as an ingredient of Sulphatrim in the following countries:

• Australia


• Bangladesh

International Drug Name Search

Cerebryl

Cerebryl may be available in the countries listed below.

Ingredient matches for Cerebryl

Piracetam

Piracetam is reported as an ingredient of Cerebryl in the following countries:

• Austria


• Georgia


• Hungary

International Drug Name Search

Midatenk

Midatenk may be available in the countries listed below.

Ingredient matches for Midatenk

Metoclopramide

Metoclopramide is reported as an ingredient of Midatenk in the following countries:

• Argentina

International Drug Name Search

Sopodorm

Sopodorm may be available in the countries listed below.

Ingredient matches for Sopodorm

Midazolam

Midazolam is reported as an ingredient of Sopodorm in the following countries:

• Poland

International Drug Name Search

Ziremex

Ziremex may be available in the countries listed below.

Ingredient matches for Ziremex

Nimodipine

Nimodipine is reported as an ingredient of Ziremex in the following countries:

• Greece

International Drug Name Search

Glibenil

Glibenil may be available in the countries listed below.

Ingredient matches for Glibenil

Glibenclamide

Glibenclamide is reported as an ingredient of Glibenil in the following countries:

• Venezuela

International Drug Name Search

Strophantin

Strophantin may be available in the countries listed below.

Ingredient matches for Strophantin

Strophanthin-K

Strophanthin-K is reported as an ingredient of Strophantin in the following countries:

• Georgia

International Drug Name Search

Coral

In the US, Coral (coral systemic).

US matches:

• Coral

Ingredient matches for Coral

Diclofenac

Diclofenac sodium salt (a derivative of Diclofenac) is reported as an ingredient of Coral in the following countries:

• Mexico

Nifedipine

Nifedipine is reported as an ingredient of Coral in the following countries:

• Italy

International Drug Name Search

Propafenon-CT

Propafenon-CT may be available in the countries listed below.

Ingredient matches for Propafenon-CT

Propafenone

Propafenone hydrochloride (a derivative of Propafenone) is reported as an ingredient of Propafenon-CT in the following countries:

• Germany

International Drug Name Search

Albamast

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Albamast

Novobiocin

Novobiocin sodium salt (a derivative of Novobiocin) is reported as an ingredient of Albamast in the following countries:

• United States

International Drug Name Search

Buspiron HCl Merck

Buspiron HCl Merck may be available in the countries listed below.

Ingredient matches for Buspiron HCl Merck

Buspirone

Buspirone hydrochloride (a derivative of Buspirone) is reported as an ingredient of Buspiron HCl Merck in the following countries:

• Netherlands

International Drug Name Search

Naloxoni hydrochloridum

Naloxoni hydrochloridum may be available in the countries listed below.

Ingredient matches for Naloxoni hydrochloridum

Naloxone

Naloxone hydrochloride (a derivative of Naloxone) is reported as an ingredient of Naloxoni hydrochloridum in the following countries:

• Latvia

International Drug Name Search

Thiabendazole

In the US, Thiabendazole (thiabendazole systemic) is a member of the drug class anthelmintics and is used to treat Angiostrongylosis, Ascariasis, Capillariasis, Cutaneous Larva Migrans, Dracunculiasis, Hookworm Infection - Necator or Ancylostoma, Strongyloidiasis, Trichinosis, Trichostrongylosis, Visceral Larva Migrans - Toxicariasis and Whipworm Infection.

US matches:

• Thiabendazole


• Thiabendazole Suspension


• Thiabendazole Topical

Ingredient matches for Thiabendazole

Tiabendazole

Thiabendazole (BAN, USAN) is also known as Tiabendazole (Rec.INN)

International Drug Name Search

Glossary

BAN	British Approved Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Moclostad

Moclostad may be available in the countries listed below.

Ingredient matches for Moclostad

Moclobemide

Moclobemide is reported as an ingredient of Moclostad in the following countries:

• Denmark

International Drug Name Search

Coccilyse

Coccilyse may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Coccilyse

Sulfadimethoxine

Sulfadimethoxine sodium (a derivative of Sulfadimethoxine) is reported as an ingredient of Coccilyse in the following countries:

• France

International Drug Name Search

Concentre d'Antithrombine III Baxter

Concentre d'Antithrombine III Baxter may be available in the countries listed below.

Ingredient matches for Concentre d'Antithrombine III Baxter

Antithrombin Iii

Antithrombin III is reported as an ingredient of Concentre d'Antithrombine III Baxter in the following countries:

• Belgium

International Drug Name Search

Clebudan

Clebudan may be available in the countries listed below.

Ingredient matches for Clebudan

Budesonide

Budesonide is reported as an ingredient of Clebudan in the following countries:

• Chile

International Drug Name Search

Reflin

Reflin may be available in the countries listed below.

Ingredient matches for Reflin

Cefazolin

Cefazolin is reported as an ingredient of Reflin in the following countries:

• Lithuania

Cefazolin sodium salt (a derivative of Cefazolin) is reported as an ingredient of Reflin in the following countries:

• India


• Latvia


• Peru

International Drug Name Search

Cor-Aspi

Cor-Aspi may be available in the countries listed below.

Ingredient matches for Cor-Aspi

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Cor-Aspi in the following countries:

• Peru

International Drug Name Search

Cerebrol

Cerebrol may be available in the countries listed below.

Ingredient matches for Cerebrol

Piracetam

Piracetam is reported as an ingredient of Cerebrol in the following countries:

• Ecuador

International Drug Name Search

Cholebine-Mini

Cholebine-Mini may be available in the countries listed below.

Ingredient matches for Cholebine-Mini

Colestilan

Colestilan is reported as an ingredient of Cholebine-Mini in the following countries:

• Japan

International Drug Name Search

Metsal

Metsal may be available in the countries listed below.

Ingredient matches for Metsal

Methyl Salicylate

Methyl Salicylate is reported as an ingredient of Metsal in the following countries:

• Singapore

Trolamine

Trolamine salicylate (a derivative of Trolamine) is reported as an ingredient of Metsal in the following countries:

• Australia

International Drug Name Search

Zidalev

Zidalev may be available in the countries listed below.

Ingredient matches for Zidalev

Levofloxacin

Levofloxacin hemihydrate (a derivative of Levofloxacin) is reported as an ingredient of Zidalev in the following countries:

• Indonesia

International Drug Name Search

Ampicilina Biocrom

Ampicilina Biocrom may be available in the countries listed below.

Ingredient matches for Ampicilina Biocrom

Ampicillin

Ampicillin trihydrate (a derivative of Ampicillin) is reported as an ingredient of Ampicilina Biocrom in the following countries:

• Argentina

International Drug Name Search

Clotrimazol Lindopharm

Clotrimazol Lindopharm may be available in the countries listed below.

Ingredient matches for Clotrimazol Lindopharm

Clotrimazole

Clotrimazole is reported as an ingredient of Clotrimazol Lindopharm in the following countries:

• Germany

International Drug Name Search

Dexarazoxane Martian

Dexarazoxane Martian may be available in the countries listed below.

Ingredient matches for Dexarazoxane Martian

Dexrazoxane

Dexrazoxane hydrochloride (a derivative of Dexrazoxane) is reported as an ingredient of Dexarazoxane Martian in the following countries:

• Argentina

International Drug Name Search

Cerestabon

Cerestabon may be available in the countries listed below.

Ingredient matches for Cerestabon

Idebenone

Idebenone is reported as an ingredient of Cerestabon in the following countries:

• Portugal

International Drug Name Search

Lodistad

Lodistad may be available in the countries listed below.

Ingredient matches for Lodistad

Felodipine

Felodipine is reported as an ingredient of Lodistad in the following countries:

• Philippines

International Drug Name Search

Clorzoxazonã

Clorzoxazonã may be available in the countries listed below.

Ingredient matches for Clorzoxazonã

Chlorzoxazone

Chlorzoxazone is reported as an ingredient of Clorzoxazonã in the following countries:

• Romania

International Drug Name Search

Dihydrotachystérol

Dihydrotachystérol may be available in the countries listed below.

Ingredient matches for Dihydrotachystérol

Dihydrotachysterol

Dihydrotachystérol (DCF) is known as Dihydrotachysterol in the US.

International Drug Name Search

Glossary

DCF	Dénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Ausgem

Ausgem may be available in the countries listed below.

Ingredient matches for Ausgem

Gemfibrozil

Gemfibrozil is reported as an ingredient of Ausgem in the following countries:

• Australia

International Drug Name Search

Zoltem

Zoltem may be available in the countries listed below.

Ingredient matches for Zoltem

Ondansetron

Ondansetron hydrochloride (a derivative of Ondansetron) is reported as an ingredient of Zoltem in the following countries:

• Bosnia & Herzegowina

International Drug Name Search

Depo-Clinovir

Depo-Clinovir may be available in the countries listed below.

Ingredient matches for Depo-Clinovir

Medroxyprogesterone

Medroxyprogesterone 17α-acetate (a derivative of Medroxyprogesterone) is reported as an ingredient of Depo-Clinovir in the following countries:

• Germany

International Drug Name Search

Cazaprol

Cazaprol may be available in the countries listed below.

Ingredient matches for Cazaprol

Cilazapril

Cilazapril is reported as an ingredient of Cazaprol in the following countries:

• Croatia (Hrvatska)


• Poland

International Drug Name Search

Citalopram RPG

Citalopram RPG may be available in the countries listed below.

Ingredient matches for Citalopram RPG

Citalopram

Citalopram hydrobromide (a derivative of Citalopram) is reported as an ingredient of Citalopram RPG in the following countries:

• France

International Drug Name Search

Reproterol Hydrochloride

Reproterol Hydrochloride may be available in the countries listed below.

Ingredient matches for Reproterol Hydrochloride

Reproterol

Reproterol Hydrochloride (BANM, USAN) is also known as Reproterol (Rec.INN)

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Cholvast

Cholvast may be available in the countries listed below.

Ingredient matches for Cholvast

Atorvastatin

Atorvastatin calcium (a derivative of Atorvastatin) is reported as an ingredient of Cholvast in the following countries:

• Turkey

International Drug Name Search

Terra Cortril

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Terra-Cortril

Hydrocortisone

Hydrocortisone is reported as an ingredient of Terra-Cortril in the following countries:

• Belgium


• Japan


• Norway


• United States

Hydrocortisone 21-acetate (a derivative of Hydrocortisone) is reported as an ingredient of Terra-Cortril in the following countries:

• South Africa


• United States

Oxytetracycline

Oxytetracycline is reported as an ingredient of Terra-Cortril in the following countries:

• South Africa

Oxytetracycline hydrochloride (a derivative of Oxytetracycline) is reported as an ingredient of Terra-Cortril in the following countries:

• Belgium


• Japan


• Norway


• South Africa


• United States

Polymyxin B

Polymyxin B sulfate (a derivative of Polymyxin B) is reported as an ingredient of Terra-Cortril in the following countries:

• South Africa

International Drug Name Search

Amlodipin Sandoz

Amlodipin Sandoz may be available in the countries listed below.

Ingredient matches for Amlodipin Sandoz

Amlodipine

Amlodipine besilate (a derivative of Amlodipine) is reported as an ingredient of Amlodipin Sandoz in the following countries:

• Austria


• Denmark


• Sweden

Amlodipine mesilate (a derivative of Amlodipine) is reported as an ingredient of Amlodipin Sandoz in the following countries:

• Norway

International Drug Name Search

Vanco-IPR

Vanco-IPR may be available in the countries listed below.

Ingredient matches for Vanco-IPR

Vancomycin

Vancomycin hydrochloride (a derivative of Vancomycin) is reported as an ingredient of Vanco-IPR in the following countries:

• Germany

International Drug Name Search

Dramanyl

Dramanyl may be available in the countries listed below.

Ingredient matches for Dramanyl

Dimenhydrinate

Dimenhydrinate is reported as an ingredient of Dramanyl in the following countries:

• El Salvador


• Guatemala


• Honduras

International Drug Name Search

Nicotrol Inhaler

Nicotrol Inhaler is a brand name of nicotine, approved by the FDA in the following formulation(s):

NICOTROL (nicotine - inhalant; oral)

• 
  Manufacturer: PHARMACIA AND UPJOHN
  
  Approval date: May 2, 1997
  
  Strength(s): 4MG/CARTRIDGE ^[RLD]

NICOTROL (nicotine - spray, metered; nasal)

• 
  Manufacturer: PFIZER INC
  
  Approval date: March 22, 1996
  
  Strength(s): 0.5MG/SPRAY ^[RLD]

Has a generic version of Nicotrol Inhaler been approved?

No. There is currently no therapeutically equivalent version of Nicotrol Inhaler available.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Nicotrol Inhaler. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.

Related Patents

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.

• 
  Composition to help stop smoking
  Patent 5,656,255
  Issued: August 12, 1997
  Inventor(s): Jones; Richard L.
  Assignee(s): Pharmacia & Upjohn AB
  A composition for administration to the nasal mucosa of a subject comprises a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent. The composition has a nicotine concentration in the range of about 10 to about 40 mg/ml and contains a suitable agent to produce a viscosity in the range of about 1 to about 30 centipoise. The composition assists in reduction of the desire of the subject to smoke tobacco or provides a substitute for tobacco smoking.
  
  Patent expiration dates:
  
  
  • August 12, 2014
    
  
  

See also...

• Nicotrol Inhaler Consumer Information (Wolters Kluwer)
• Nicotrol Inhaler nasal, inhalation Consumer Information (Cerner Multum)
• Nicotrol Inhaler oral/patches/nasal Consumer Information (Cerner Multum)
• Nicotrol Inhalation, oral/nebulization Advanced Consumer Information (Micromedex)
• Nicotrol Oral, Transdermal Advanced Consumer Information (Micromedex)
• Nicotine Consumer Information (Drugs.com)
• Nicotine Gum Consumer Information (Wolters Kluwer)
• Nicotine Inhaler Consumer Information (Wolters Kluwer)
• Nicotine Lozenges Consumer Information (Wolters Kluwer)
• Nicotine Patch Consumer Information (Wolters Kluwer)
• Nicotine Spray Consumer Information (Wolters Kluwer)
• Nicotine System Kit transdermal Consumer Information (Cerner Multum)
• Thrive gum, lozenge Consumer Information (Cerner Multum)
• Nicotine gum, lozenge Consumer Information (Cerner Multum)
• Nicotine nasal, inhalation Consumer Information (Cerner Multum)
• Nicotine transdermal Consumer Information (Cerner Multum)
• Nicotine Inhalation, oral/nebulization Advanced Consumer Information (Micromedex)
• Nicotine Nasal Advanced Consumer Information (Micromedex)
• Nicotine Oral, Transdermal Advanced Consumer Information (Micromedex)
• Nicotine AHFS DI Monographs (ASHP)

Hydroxyprogesterone Caproate

Hydroxyprogesterone Caproate may be available in the countries listed below.

Ingredient matches for Hydroxyprogesterone Caproate

Hydroxyprogesterone

Hydroxyprogesterone Caproate (BANM, JAN) is known as Hydroxyprogesterone in the US.

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
JAN	Japanese Accepted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Tizadin

Tizadin may be available in the countries listed below.

Ingredient matches for Tizadin

Tizanidine

Tizanidine hydrochloride (a derivative of Tizanidine) is reported as an ingredient of Tizadin in the following countries:

• Bangladesh

International Drug Name Search

Choline Theophyllinate

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

R03DA02

CAS registry number (Chemical Abstracts Service)

0004499-40-5

Chemical Formula

C12-H21-N5-O3

Molecular Weight

283

Therapeutic Categories

Antiasthmatic agent

Cardiac stimulant, cardiotonic agent

Diuretic agent

Chemical Name

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1)

Foreign Names

• Cholini Theophyllinas (Latin)
• Cholin theophyllinat (German)
• Théophyllinate de Choline (French)
• Teofilinato de colina (Spanish)

Generic Names

• Choline Theophyllinate (OS: BAN)
• Choline Theophylline (OS: JAN)
• Colina teofillinato (OS: DCIT)
• Oxtriphylline (OS: USAN)
• Choline Theophyllinate (PH: BP 2010)
• Oxtriphylline (PH: USP 32)

Brand Names

• Brondecon
  Johnson & Johnson, Australia



• Choledyl
  Galenica, Greece; Gamma, Sri Lanka; Pfizer, Belize; Pfizer, Costa Rica; Pfizer, Guatemala; Pfizer, Honduras; Pfizer, Nicaragua; Pfizer, Panama; Pfizer, El Salvador; Warner Chilcott, United States



• Teovent
  BioPhausia, Sweden



• Theocolin
  Sannova, Japan



• Theolinate
  Union Lab, Taiwan

International Drug Name Search

Glossary

BAN	British Approved Name
DCIT	Denominazione Comune Italiana
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Lisinopril-Q

Lisinopril-Q may be available in the countries listed below.

Ingredient matches for Lisinopril-Q

Lisinopril

Lisinopril dihydrate (a derivative of Lisinopril) is reported as an ingredient of Lisinopril-Q in the following countries:

• Germany

International Drug Name Search

Omeprazols

Omeprazols may be available in the countries listed below.

Ingredient matches for Omeprazols

Omeprazole

Omeprazole is reported as an ingredient of Omeprazols in the following countries:

• Lithuania

International Drug Name Search

Nonnerv

Nonnerv may be available in the countries listed below.

Ingredient matches for Nonnerv

Etizolam

Etizolam is reported as an ingredient of Nonnerv in the following countries:

• Japan

International Drug Name Search

Sinemet

In the US, Sinemet (carbidopa/levodopa systemic) is a member of the drug class dopaminergic antiparkinsonism agents and is used to treat GTP-CH Deficiency, Neuroleptic Malignant Syndrome, Parkinson's Disease and Restless Legs Syndrome.

US matches:

• Sinemet


• Sinemet CR Sustained-Release Tablets


• Sinemet CR

UK matches:

• Sinemet 12.5mg/50mg, 10mg/100mg, 25mg/100mg and 25mg/250mg Tablets
• Sinemet CR and Half Sinemet CR
• Sinemet 12.5mg/50mg, 10mg/100mg, 25mg/100mg and 25mg/250mg Tablets (SPC)
• Sinemet CR and Half Sinemet CR (SPC)

Ingredient matches for Sinemet

Carbidopa

Carbidopa is reported as an ingredient of Sinemet in the following countries:

• Argentina


• Australia


• Austria


• Brazil


• Bulgaria


• Canada


• Czech Republic


• Denmark


• Estonia


• Finland


• Greece


• Hong Kong


• Iceland


• Ireland


• Latvia


• Lithuania


• Luxembourg


• Malaysia


• Netherlands


• New Zealand


• Norway


• Oman


• Peru


• Philippines


• Poland


• Portugal


• Singapore


• South Africa


• Spain


• Sri Lanka


• Switzerland


• Taiwan


• Thailand


• Turkey


• United States


• Venezuela

Carbidopa monohydrate (a derivative of Carbidopa) is reported as an ingredient of Sinemet in the following countries:

• Belgium


• Croatia (Hrvatska)


• France


• Greece


• Hungary


• Ireland


• Italy


• Spain


• Sweden


• United Kingdom

Levodopa

Levodopa is reported as an ingredient of Sinemet in the following countries:

• Argentina


• Australia


• Austria


• Belgium


• Brazil


• Bulgaria


• Canada


• Croatia (Hrvatska)


• Czech Republic


• Denmark


• Estonia


• Finland


• France


• Greece


• Hong Kong


• Hungary


• Iceland


• Ireland


• Italy


• Latvia


• Lithuania


• Luxembourg


• Malaysia


• Netherlands


• New Zealand


• Norway


• Oman


• Peru


• Philippines


• Poland


• Portugal


• Singapore


• South Africa


• Spain


• Sri Lanka


• Sweden


• Switzerland


• Taiwan


• Thailand


• Turkey


• United Kingdom


• United States


• Venezuela

International Drug Name Search

Glossary

SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Ganadol

Ganadol may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Ganadol

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Ganadol in the following countries:

• Italy

International Drug Name Search

Glucoton

Glucoton may be available in the countries listed below.

Ingredient matches for Glucoton

Gliclazide

Gliclazide is reported as an ingredient of Glucoton in the following countries:

• Georgia

International Drug Name Search

Syntomycin Nizhpharm

Syntomycin Nizhpharm may be available in the countries listed below.

Ingredient matches for Syntomycin Nizhpharm

Chloramphenicol

Chloramphenicol is reported as an ingredient of Syntomycin Nizhpharm in the following countries:

• Latvia

International Drug Name Search

Topcef

Topcef may be available in the countries listed below.

Ingredient matches for Topcef

Cefixime

Cefixime is reported as an ingredient of Topcef in the following countries:

• Myanmar

International Drug Name Search

Coponent

Coponent may be available in the countries listed below.

Ingredient matches for Coponent

Nicardipine

Nicardipine hydrochloride (a derivative of Nicardipine) is reported as an ingredient of Coponent in the following countries:

• Japan

International Drug Name Search

Flurop

Flurop may be available in the countries listed below.

Ingredient matches for Flurop

Fluorometholone

Fluorometholone is reported as an ingredient of Flurop in the following countries:

• Portugal

International Drug Name Search

Specilid

Specilid may be available in the countries listed below.

Ingredient matches for Specilid

Nimesulide

Nimesulide is reported as an ingredient of Specilid in the following countries:

• Georgia


• Greece

International Drug Name Search

Imodiumlingual

Imodiumlingual may be available in the countries listed below.

Ingredient matches for Imodiumlingual

Loperamide

Loperamide hydrochloride (a derivative of Loperamide) is reported as an ingredient of Imodiumlingual in the following countries:

• France

International Drug Name Search

Duro-Tuss Expectorant

Duro-Tuss Expectorant may be available in the countries listed below.

Ingredient matches for Duro-Tuss Expectorant

Bromhexine

Bromhexine hydrochloride (a derivative of Bromhexine) is reported as an ingredient of Duro-Tuss Expectorant in the following countries:

• Singapore

Pholcodine

Pholcodine is reported as an ingredient of Duro-Tuss Expectorant in the following countries:

• Singapore

International Drug Name Search

KCl Sintetica

KCl Sintetica may be available in the countries listed below.

Ingredient matches for KCl Sintetica

Potassium Chloride

Potassium Chloride is reported as an ingredient of KCl Sintetica in the following countries:

• Switzerland

International Drug Name Search

Enterodar

Enterodar may be available in the countries listed below.

Ingredient matches for Enterodar

Nifuroxazide

Nifuroxazide is reported as an ingredient of Enterodar in the following countries:

• Mexico

International Drug Name Search

Muconasal

Muconasal may be available in the countries listed below.

Ingredient matches for Muconasal

Tramazoline

Tramazoline is reported as an ingredient of Muconasal in the following countries:

• Romania

Tramazoline hydrochloride (a derivative of Tramazoline) is reported as an ingredient of Muconasal in the following countries:

• Czech Republic


• Slovakia

International Drug Name Search

Vigor

Vigor may be available in the countries listed below.

Ingredient matches for Vigor

Sildenafil

Sildenafil citrate (a derivative of Sildenafil) is reported as an ingredient of Vigor in the following countries:

• Argentina

International Drug Name Search

Calcitriolo DOC

Calcitriolo DOC may be available in the countries listed below.

Ingredient matches for Calcitriolo DOC

Calcitriol

Calcitriol is reported as an ingredient of Calcitriolo DOC in the following countries:

• Italy

International Drug Name Search

Bamyl

Bamyl may be available in the countries listed below.

Ingredient matches for Bamyl

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Bamyl in the following countries:

• China


• Sweden

International Drug Name Search

Klacid Saft

Klacid Saft may be available in the countries listed below.

Ingredient matches for Klacid Saft

Clarithromycin

Clarithromycin is reported as an ingredient of Klacid Saft in the following countries:

• Germany

International Drug Name Search

Depakene

Generic Name: valproic acid (Oral route)

val-PROE-ik AS-id

Oral route(Syrup;Capsule, Liquid Filled;Capsule, Delayed Release)

Hepatic failure resulting in fatalities has occurred in patients receiving valproic acid and its derivatives. Children under the age of two years are at a considerably increased risk of developing fatal hepatotoxicity. Patients should be monitored closely and liver function tests should be performed prior to therapy and at frequent intervals thereafter, especially during the first six months. Life-threatening pancreatitis has been reported in both children and adults receiving valproate. If pancreatitis is diagnosed, valproate should ordinarily be discontinued. Valproate can produce teratogenic effects such as neural tube defects (eg, spina bifida). Accordingly, the use of valproate products in women of childbearing potential requires that the benefits of its use be weighed against the risk of injury to the fetus .

Oral route(Tablet, Enteric Coated;Tablet, Extended Release;Capsule, Delayed Release)

Hepatotoxicity (some cases fatal), usually occurring during the first 6 months of treatment, has been reported in patients receiving valproic acid and its derivatives. Children under the age of two years are at a considerably increased risk of developing fatal hepatotoxicity. Monitor patients closely, and perform liver function tests prior to therapy and at frequent intervals thereafter. Valproate can produce teratogenic effects such as neural tube defects (eg, spina bifida). Accordingly, the use of divalproex sodium in women of childbearing potential requires that the benefits of its use be weighed against the risk of injury to the fetus. Life-threatening pancreatitis has been reported in both children and adults receiving valproate. If pancreatitis is diagnosed, valproate should ordinarily be discontinued .

Commonly used brand name(s)

In the U.S.

• Depakene


• Depakote


• Depakote DR


• Depakote ER


• Depakote Sprinkles


• Stavzor

In Canada

• Alti-Valproic

Available Dosage Forms:

• Capsule, Delayed Release


• Syrup


• Capsule, Liquid Filled


• Tablet, Extended Release


• Tablet, Enteric Coated


• Tablet, Delayed Release

Therapeutic Class: Antimanic

Pharmacologic Class: Histone Deacetylase Inhibitor

Chemical Class: Valproic Acid (class)

Uses For Depakene

Valproic acid is used alone or together with other medicines to control certain types of seizures (convulsions) in the treatment of epilepsy. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

Valproic acid is also used to treat the manic phase of bipolar disorder (manic-depressive illness), and helps prevent migraine headaches.

This medicine is available only with your doctor's prescription.

Before Using Depakene

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of valproic acid in children. However, safety and efficacy have not been established in children with epilepsy below 10 years of age; and in children with migraine below 12 years of age. Because of valproic acid's toxicity, use in children below 2 years of age requires extreme caution.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of valproic acid in the elderly. However, elderly patients are more likely to have unwanted effects (e.g., tremors or unusual drowsiness), which may require an adjustment in the dose for patients receiving valproic acid.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Doripenem


• Ertapenem


• Imipenem


• Ketorolac


• Lamotrigine


• Meropenem


• Naproxen


• Primidone


• Vorinostat


• Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acyclovir


• Aspirin


• Betamipron


• Carbamazepine


• Cholestyramine


• Clomipramine


• Erythromycin


• Ethosuximide


• Felbamate


• Fosphenytoin


• Ginkgo


• Lopinavir


• Lorazepam


• Mefloquine


• Nimodipine


• Nortriptyline


• Olanzapine


• Oxcarbazepine


• Panipenem


• Phenobarbital


• Phenytoin


• Rifampin


• Rifapentine


• Risperidone


• Ritonavir


• Rufinamide


• Topiramate


• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Brain disease, severe or


• Congenital metabolism disorders (born with a disease that affects metabolism) or


• Mental retardation with severe seizure disorders—Use with caution. May increase risk for more serious side effects.

• Liver disease or


• Urea cycle disorder (genetic disorder)—Should not be used in patients with these conditions.

• Pancreatitis (inflammation of the pancreas) or


• Thrombocytopenia (low platelet count)—May make these conditions worse.

Proper Use of valproic acid

This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Depakene. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a medication guide and patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules and oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules, delayed-release capsules, and solution):
  
  • For seizures:
    
    • Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight a day to start. Your doctor may increase your dose gradually every week by 5 to 10 mg per kg of body weight if needed. However, the dose is usually not more than 60 mg per kg of body weight a day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken two or more times during the day.
    
    
    • Children below 10 years of age—Use and dose must be determined by your doctor.
    
    
  
  


• For oral dosage form (delayed-release capsules):
  
  • For mania:
    
    • Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For migraine:
    
    • Adults—At first, 250 milligrams (mg) two times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Depakene

It is very important that your doctor check your progress closely while you are using this medicine to see if it is working properly and to allow for a change in the dose. Blood tests may be needed to check for any unwanted effects.

Using this medicine while you are pregnant (especially during first trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

It is very important to take folic acid before getting pregnant and during early pregnancy to lower chances of harmful side effects to your unborn baby. Ask your doctor or pharmacist for help if you are not sure how to choose a folic acid product.

Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Check with your doctor right away if you are having unusual drowsiness, dullness, tiredness, weakness or feelings of sluggishness, changes in mental status, or vomiting. These may be symptoms of a serious condition called hyperammonemic encephalopathy.

Valproic acid may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Valproic acid may cause serious allergic reactions that affect several parts of the body (e.g., liver or kidney). Check with your doctor right away if you have more than one of the following symptoms: fever; dark urine; headache; rash; stomach pain; swollen lymph glands in the neck, armpit, or groin; unusual tiredness; or yellow eyes or skin.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.

Check with your doctor if you have unusual drowsiness, dullness, tiredness, weakness; or feeling of sluggishness; confusion; low body temperature; or loss of consciousness while taking this medicine.

Valproic acid may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you notice any of these adverse effects, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Depakene Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Black, tarry stools


• bleeding gums


• bloating or swelling of the face, arms, hands, lower legs, or feet


• blood in the urine or stools


• confusion


• cough or hoarseness


• crying


• delusions


• dementia


• depersonalization


• diarrhea


• difficult or labored breathing


• dysphoria


• euphoria


• fever or chills


• general feeling of discomfort or illness


• headache


• joint pain


• loss of appetite


• lower back or side pain


• mental depression


• muscle aches and pains


• nausea


• nervousness


• painful or difficult urination


• paranoia


• pinpoint red spots on the skin


• quick to react or overreact emotionally


• rapid weight gain


• rapidly changing moods


• runny nose


• shakiness in the legs, arms, hands, or feet


• shivering


• shortness of breath


• sleepiness or unusual drowsiness


• sore throat


• sweating


• tightness in the chest


• tingling of the hands or feet


• trembling or shaking of the hands or feet


• trouble with sleeping


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight gain or loss


• vomiting


• wheezing

Less common

• Abnormal dreams


• absence of or decrease in body movement


• anxiety


• bloody nose


• bloody or cloudy urine


• blurred vision


• bruising burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• change in personality


• change in walking and balance


• changes in patterns and rhythms of speech


• chest pain


• chills


• clumsiness or unsteadiness


• cold sweats


• constipation


• darkened urine


• degenerative disease of the joint


• difficult, burning, or painful urination


• difficulty with moving


• discouragement


• dizziness


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• dry mouth


• excessive muscle tone


• fast, irregular, pounding, or racing heartbeat or pulse


• fear


• feeling of warmth or heat


• feeling sad or empty


• flushing or redness of the skin, especially on the face and neck


• frequent urge to urinate


• heavy non-menstrual vaginal bleeding


• hyperventilation


• increased need to urinate


• indigestion


• irritability


• lack of appetite


• lack of coordination


• large, flat, blue, or purplish patches in the skin


• leg cramps


• lip smacking or puckering


• loss of bladder control


• loss of interest or pleasure


• loss of strength or energy


• multiple swollen and inflamed skin lesions


• muscle pain or stiffness


• muscle tension or tightness


• normal menstrual bleeding occurring earlier, possibly lasting longer than expected


• pains in the stomach, side, or abdomen, possibly radiating to the back


• passing urine more often


• pounding in the ears


• puffing of the cheeks


• rapid or worm-like movements of the tongue


• rapid weight gain


• restlessness


• seeing, hearing, or feeling things that are not there


• shakiness and unsteady walk


• slurred speech


• small red or purple spots on the skin


• sweating


• swollen joints


• tiredness


• trouble with concentrating


• trouble with speaking


• twitching


• uncontrolled chewing movements


• uncontrolled movements of the arms and legs


• unsteadiness, trembling, or other problems with muscle control or coordination


• vomiting of blood or material that looks like coffee grounds


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Change in consciousness


• fainting


• loss of consciousness


• slow or irregular heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• belching


• body aches or pain


• change in vision


• congestion


• continuing ringing or buzzing or other unexplained noise in the ears


• hair loss or thinning of the hair


• hearing loss


• heartburn


• impaired vision


• lack or loss of strength


• loss of memory


• problems with memory


• rash


• seeing double


• sleeplessness


• tender, swollen glands in the neck


• trouble with swallowing


• unable to sleep


• uncontrolled eye movements


• voice changes


• weight gain


• weight loss

Less common

• Absent, missed, or irregular menstrual periods


• back pain


• burning, dry, or itching eyes


• change in taste or bad unusual or unpleasant (after) taste


• coin-shaped lesions on the skin


• cough producing mucus


• cramps


• dandruff


• discharge or excessive tearing


• dry skin


• earache


• excess air or gas in the stomach or intestines


• eye pain


• feeling of constant movement of self or surroundings


• full feeling


• heavy bleeding


• increased appetite


• itching of the vagina or genital area


• itching skin


• loss of bowel control


• neck pain


• oily skin


• pain


• pain during sexual intercourse


• pain or tenderness around the eyes and cheekbones


• passing gas


• rash with flat lesions or small raised lesions on the skin


• redness or swelling in the ear


• redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid


• redness, swelling, or soreness of the tongue


• sensation of spinning


• sneezing


• stiff neck


• stopping of menstrual bleeding


• thick, white vaginal discharge with no odor or with a mild odor

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Depakene side effects (in more detail)

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More Depakene resources

• Depakene Side Effects (in more detail)
• Depakene Use in Pregnancy & Breastfeeding
• Drug Images
• Depakene Drug Interactions
• Depakene Support Group
• 3 Reviews for Depakene - Add your own review/rating

• Depakene Prescribing Information (FDA)


• Depakene MedFacts Consumer Leaflet (Wolters Kluwer)


• Valproic Acid Monograph (AHFS DI)


• Depacon MedFacts Consumer Leaflet (Wolters Kluwer)


• Depacon Prescribing Information (FDA)


• Stavzor Prescribing Information (FDA)


• Stavzor Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Stavzor Consumer Overview

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